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服务平台首页>协同创新>专家库>专家详情

吴 更(研究员)

所属单位:上海交通大学微生物代谢国家重点实验室

担任职务:研究员

擅长领域:

联系方式:021-34205914 邮箱:登录后查看

 个人简介

1997年在中国科学技术大学生物系获学士学位,2001年在普林斯顿大学化学系获博士学位。发表SCI论文44篇,被引用超过2200次。曾分别在Nature、Molecular Cell和Science上发表第一作者论文,已分别被引用464次、281次和152次。所解析的Smac-XIAP蛋白质复合物的晶体结构被Genentech、Novartis等制药公司作为研发抗癌药物的参考依据,研发出的某些化合物已用于临床实验。2008年开始在上海交大担任教授、博士生导师,作为独立PI建立了上海交大第一个、也是目前上海交大闵行校区唯一一个结构生物学实验室。以通讯作者身份在Cell Research、Molecular Microbiology等SCI期刊上发表8篇论文。获上海市“东方学者”特聘教授(2008)、上海市“曙光学者”(2008)、上海市“浦江人才”(2009)、教育部“新世纪优秀人才”(2009)等荣誉。读博士、博士后期间,在Nature(2000年,该论文被Novartis等制药公司作为开发抗癌药物的参考依据)、Science(2000年)、Molecular Cell(2003, 2004年)发表第一作者论文。在交大期间,在Nature Communications (2013, 2017年)、Cell Research(2012年, 该论文被英国皇家学会院士Mariann Bienz选入国际生物医药类论文权威数据库Faculty of 1000)、Nucleic Acids Research(2014年)、Molecular Microbiology(2013, 2014年)、Journal of Molecular Cell Biology(2016年)、Cell Discovery(2015, 2016年)等发表通讯作者或第一作者论文。

教育经历

1999.5 – 2001.5  普林斯顿大学(美国) 化学系  博士

1997.8 – 1999.5  普林斯顿大学(美国) 化学系  硕士

1992.9 – 1997.7  中国科学技术大学   生物系  学士  化学物理学辅修学位

1997 -  2001    普林斯顿大学      化学系  硕士、博士学位

工作经历

2008.6–现在     上海交通大学生命科学技术学院  教授、博士生导师

2003.6–2008.6   哈佛大学医学院/波士顿儿童医院(美国) 博士后

2001.6–2003.6   Memorial Sloan Kettering癌症研究所/Howard Hughes Medical Institute(美国) 博士后

荣誉奖励

获美国Leukemia and Lymphoma Society的Special Fellowship(2005-2008年)、上海市“东方学者”特聘教授(2008年)与上海市“东方学者”跟踪计划(2014年)、上海市“曙光计划”(2008年)、教育部 “新世纪优秀人才”(2009年)、上海市“浦江人才”(2009年)等荣誉。荣获教育部“高等学校科学研究优秀成果奖(科学技术)”自然科学一等奖(排名第四,2016年)。指导的博士生张振义荣获2014年上海市优秀博士论文。


 

 

 

主要成就


  • 代表性论文(*:共同通讯作者,#:并列第一作者)

    1.         Kulaberoglu Y#, Lin K#, Holder M, Gai Z, Gomez M, Shifa BA, Mavis M, Hua L, Sharif AAD, Lujan C, Smith EJ, Bjedov I, Tapon N, Wu G*, Hergovich A*. Stable MOB1 interaction with Warts/LATS, not Hippo/MST, is essential for development and tissue growth control in Hippo signaling. Nat Commun Accepted. (2017)
    2.         Qian T, Wo J, Zhang Y, Song Q, Feng G, Luo R, Lin S*, Wu G*, Chen HF*. Crystal structure of StnA for the biosynthesis of antitumor drug streptonigrin reveals a unique substrate binding mode. Sci Rep 7:40254. (2017)
    3.         Gai Z, Wang Q, Yang C, Wang L, Deng W, Wu G*. Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway. Cell Discov 2:16051. (2016)
    4.         Gai Z, Chu W, Deng W, Li W, Li H, He A, Nellist M, Wu G*. Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region. J Mol Cell Biol 8:411-425. (2016)
    5.         Zhao G, Chen C, Xiong W, Gao T, Deng Z, Wu G*, He X*. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis. Sci Rep 6:39675. (2016)
    6.         Zhang Z, Akyildiz S, Xiao Y, Gai Z, An Y, Behrens J*, Wu G*. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners. Cell Discov 1:15016. (2015)
    7.         Wu G#, Chen D#, Tang H#, Ren Y, Chen Q, Lv Y, Zhang Z, Zhao YL*, Yao Y, Xu P*. Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases. Mol Microbiol 91:1009-1021. (2014)
    8.         Zhao G#, Wu G#, Zhang Y, Liu G, Han T, Deng Z, He X*. Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry. Nucleic Acids Res 42:8115-24. (2014)
    9.         Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y*, Wu G*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 4:2608. (2013)
    10.     Chen D, Tang H, Lv Y, Zhang Z, Shen K, Lin K, Zhao YL, Wu G*, Xu P*. Structural and computational studies of the maleate isomerase Iso from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside. Mol Microbiol 87:1237-1244. (2013)
    11.     Zhang Z, Chen L, Gao L, Lin K*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J*, Wu G*. Structural basis for the recognition of Asef by Adenomatous Polyposis Coli. Cell Res 22:372-386. (2012) 被英国皇家学会院士Marian Bienz选入Faculty of 1000数据库
    其他SCI论文:
    12.     Jiang H, Deng R, Yuang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J*, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol Accepted. (2017)
    13.     Zhang K, Wu G, Tang H*, Hu C, Shi T, Xu P*. Structural basis for the transcriptional repressor NicR2 in nicotine degradation from Pseudomonas. Mol Microbiol 103:165-180. (2017)
    14.     21. Liu G, Zhang Z, Zhao G, Deng Z, Wu G*, He X*. Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA. Acta Crystallogr F 71:57-60. (2015)
    15.     Jiang Y, Tang H*, Wu G, Xu P*. Functional identification of a novel gene, moaE, for 3-succinoylpyridine degradation in Pseudomonas putida S16. Sci Rep 5:13464. (2015)
    16.     Zhang Y, An J, Yang G, Bai A, Zheng B, Lou Z, Wu G, Ye W, Chen HF, Feng Y*, Manco G*. Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426. PLoS One 10:e0115130. (2015)
    17.     Wang H, Zhang Y, Zhang Z, Jin WL*, Wu G*. Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein. Acta Crystallogr F 70:123-126. (2014)
    18.     Xie Y, An J, Yang G, Wu G, Zhang Y, Cui L, Feng Y*. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J Biol Chem 289:7994-8006. (2014)
    19.     Li A, Zhang Y*, Wang C, Wu G*, Wang Z. Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. World J Microbiol Biotechnol 29:1941-1949 (2013)
    20.     Chen F, Zhang Z, Lin K*, Qian T, Zhang Y, You D, He X, Wang Z, Liang J, Deng Z, Wu G*. Crystal structure of the cysteine desulfurase DndA of Streptomyces lividans which is involved in DNA phosphorothioation. PLoS One 7:e36635. (2012)
    21.     Hu W, Wang C, Liang J, Zhang T, Hu Z, Wang Z, Lan W, Li F, Wu H, Ding J, Wu G, Deng Z, Cao C*. Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification. Cell Res 22:1203-1206. (2012)
    22.     Tang H, Yao Y, Wang L, Yu H, Ren Y, Wu G, Xu P*. Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci Rep 2:377. (2012)
    23.     Li Q, Feng J, Gao C, Li F, Yu C, Meng L, Zhang Z, Ma C*, Gu L*, Wu G, Xu P. Purification and characterization of a flavin reductase from the biodesulfurizing bacterium Mycobacterium goodii X7B. Process Biochem 47:1144-1149. (2012)